Step back from the edge

Reorganizing Canadian Libraries: A Giant Step Back from the Front

THENAGGING QcxmoivOF WIO DOES wHxr in libraries has been exacerbated in recent years by significant restructuring initiatives, driven by ongoing budgetary pressures and constant technological change. In the study reported here, senior administrators as well as middle managers and frontline librarians in public and academic library settings were asked to describe the nature of organizational cha...

One step forwards, one step back.

The Next Step Forward Is to Take a Step Back.

Understanding the causes of diabetes is at the heart of most diabetes research. The field of causal inference has made dramatic advances in methodology that allows for causal inference from observational and not experimental data (1). One such methodological advancement is the use of genetic markers as instrumental variables, or so-called Mendelian randomization (MR) (2). MR relies on the laws ...

Cells step back in time

Models based on the crystal structure of interleukin-1 vary significantly. D eP ri st o/ El se vi er UK) warns that, for any given structure in the Protein Data Bank (PDB), there will be many other overlooked structures that are equally consistent with the data. Crystallized proteins retain the ability to move around, thus making interpretations of diffraction data an imprecise process. Crystal...

Taking a Step Back from Back-Translocation: an Integrative View of LepA/EF4's Cellular Function.

Protein synthesis, the translation of mRNA into a polypeptide facilitated by the ribosome, is assisted by a variety of protein factors, some of which are GTPases. In addition to four highly conserved and well-understood GTPases with known function, there are also a number of noncanonical GTPases that are implicated in translation but whose functions are not fully understood. LepA/EF4 is one of ...